Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

Ene reductases from the Old Yellow Enzyme (OYE) family are industrially interesting enzymes for the biocatalytic asymmetric reduction of alkenes. To access both enantiomers of the target reduced products, stereocomplementary pairs of OYE enzymes are necessary, but their natural occurrence is quite l...

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Detalles Bibliográficos
Publicado en:Front Bioeng Biotechnol
Main Authors: Crotti, Michele, Parmeggiani, Fabio, Ferrandi, Erica Elisa, Gatti, Francesco G., Sacchetti, Alessandro, Riva, Sergio, Brenna, Elisabetta, Monti, Daniela
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Bioengineering and Biotechnology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497740/
https://ncbi.nlm.nih.gov/pubmed/31080798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2019.00089
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