Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

Ene reductases from the Old Yellow Enzyme (OYE) family are industrially interesting enzymes for the biocatalytic asymmetric reduction of alkenes. To access both enantiomers of the target reduced products, stereocomplementary pairs of OYE enzymes are necessary, but their natural occurrence is quite l...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Main Authors: Crotti, Michele, Parmeggiani, Fabio, Ferrandi, Erica Elisa, Gatti, Francesco G., Sacchetti, Alessandro, Riva, Sergio, Brenna, Elisabetta, Monti, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Bioengineering and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497740/
https://ncbi.nlm.nih.gov/pubmed/31080798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2019.00089
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