Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

Ene reductases from the Old Yellow Enzyme (OYE) family are industrially interesting enzymes for the biocatalytic asymmetric reduction of alkenes. To access both enantiomers of the target reduced products, stereocomplementary pairs of OYE enzymes are necessary, but their natural occurrence is quite l...

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Bibliografische gegevens
Gepubliceerd in:Front Bioeng Biotechnol
Hoofdauteurs: Crotti, Michele, Parmeggiani, Fabio, Ferrandi, Erica Elisa, Gatti, Francesco G., Sacchetti, Alessandro, Riva, Sergio, Brenna, Elisabetta, Monti, Daniela
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2019
Onderwerpen:
Bioengineering and Biotechnology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497740/
https://ncbi.nlm.nih.gov/pubmed/31080798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2019.00089
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