Stereoselectivity Switch in the Reduction of α-Alkyl-β-Arylenones by Structure-Guided Designed Variants of the Ene Reductase OYE1

Ene reductases from the Old Yellow Enzyme (OYE) family are industrially interesting enzymes for the biocatalytic asymmetric reduction of alkenes. To access both enantiomers of the target reduced products, stereocomplementary pairs of OYE enzymes are necessary, but their natural occurrence is quite l...

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Détails bibliographiques
Publié dans:Front Bioeng Biotechnol
Auteurs principaux: Crotti, Michele, Parmeggiani, Fabio, Ferrandi, Erica Elisa, Gatti, Francesco G., Sacchetti, Alessandro, Riva, Sergio, Brenna, Elisabetta, Monti, Daniela
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2019
Sujets:
Bioengineering and Biotechnology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497740/
https://ncbi.nlm.nih.gov/pubmed/31080798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2019.00089
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