Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer

Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we analysis structural variations (SVs) and mutational signatures via whole-genome sequencing of 168 GCs. Our data demonstrates diverse models of complex SVs operative in GC, which l...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Nat Commun
Κύριοι συγγραφείς: Xing, Rui, Zhou, Yong, Yu, Jun, Yu, Yingyan, Nie, Yongzhan, Luo, Wen, Yang, Chao, Xiong, Teng, Wu, William K. K., Li, Zhongwu, Bing, Yang, Lin, Shuye, Zhang, Yaping, Hu, Yingqi, Li, Lin, Han, Lijuan, Yang, Chen, Huang, Shaogang, Huang, Suiping, Zhou, Rui, Li, Jing, Wu, Kaichun, Fan, Daiming, Tang, Guangbo, Dou, Jianhua, Zhu, Zhenggang, Ji, Jiafu, Fang, Xiaodong, Lu, Youyong
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group UK 2019
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Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497673/
https://ncbi.nlm.nih.gov/pubmed/31048690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09644-6
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