Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer

Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we analysis structural variations (SVs) and mutational signatures via whole-genome sequencing of 168 GCs. Our data demonstrates diverse models of complex SVs operative in GC, which l...

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Publicado no:Nat Commun
Main Authors: Xing, Rui, Zhou, Yong, Yu, Jun, Yu, Yingyan, Nie, Yongzhan, Luo, Wen, Yang, Chao, Xiong, Teng, Wu, William K. K., Li, Zhongwu, Bing, Yang, Lin, Shuye, Zhang, Yaping, Hu, Yingqi, Li, Lin, Han, Lijuan, Yang, Chen, Huang, Shaogang, Huang, Suiping, Zhou, Rui, Li, Jing, Wu, Kaichun, Fan, Daiming, Tang, Guangbo, Dou, Jianhua, Zhu, Zhenggang, Ji, Jiafu, Fang, Xiaodong, Lu, Youyong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497673/
https://ncbi.nlm.nih.gov/pubmed/31048690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09644-6
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