Whole-genome sequencing reveals novel tandem-duplication hotspots and a prognostic mutational signature in gastric cancer

Genome-wide analysis of genomic signatures might reveal novel mechanisms for gastric cancer (GC) tumorigenesis. Here, we analysis structural variations (SVs) and mutational signatures via whole-genome sequencing of 168 GCs. Our data demonstrates diverse models of complex SVs operative in GC, which l...

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Publicado en:Nat Commun
Autores principales: Xing, Rui, Zhou, Yong, Yu, Jun, Yu, Yingyan, Nie, Yongzhan, Luo, Wen, Yang, Chao, Xiong, Teng, Wu, William K. K., Li, Zhongwu, Bing, Yang, Lin, Shuye, Zhang, Yaping, Hu, Yingqi, Li, Lin, Han, Lijuan, Yang, Chen, Huang, Shaogang, Huang, Suiping, Zhou, Rui, Li, Jing, Wu, Kaichun, Fan, Daiming, Tang, Guangbo, Dou, Jianhua, Zhu, Zhenggang, Ji, Jiafu, Fang, Xiaodong, Lu, Youyong
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497673/
https://ncbi.nlm.nih.gov/pubmed/31048690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09644-6
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