The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death

Reactive oxygen species (ROS) play a key role in development of heart failure but, at a cellular level, their effects range from cytoprotection to induction of cell death. Understanding how this is regulated is crucial to develop novel strategies to ameliorate only the detrimental effects. Here, we...

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Bibliografske podrobnosti
izdano v:J Mol Cell Cardiol
Main Authors: Meijles, Daniel N., Zoumpoulidou, Georgia, Markou, Thomais, Rostron, Kerry A., Patel, Rishi, Lay, Kenneth, Handa, Balvinder S., Wong, Bethany, Sugden, Peter H., Clerk, Angela
Format: Artigo
Jezik:Inglês
Izdano: Academic Press 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497135/
https://ncbi.nlm.nih.gov/pubmed/30771309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.02.006
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