The cardiomyocyte “redox rheostat”: Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death

Reactive oxygen species (ROS) play a key role in development of heart failure but, at a cellular level, their effects range from cytoprotection to induction of cell death. Understanding how this is regulated is crucial to develop novel strategies to ameliorate only the detrimental effects. Here, we...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Meijles, Daniel N., Zoumpoulidou, Georgia, Markou, Thomais, Rostron, Kerry A., Patel, Rishi, Lay, Kenneth, Handa, Balvinder S., Wong, Bethany, Sugden, Peter H., Clerk, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497135/
https://ncbi.nlm.nih.gov/pubmed/30771309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2019.02.006
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