Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

Systemic hypertension increases cardiac workload causing cardiomyocyte hypertrophy and increased cardiac fibrosis. An underlying feature is increased production of reactive oxygen species. Redox-sensitive ASK1 (apoptosis signal-regulating kinase 1) activates stress-regulated protein kinases (p38-MAP...

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Detalhes bibliográficos
Publicado no:Hypertension
Main Authors: Meijles, Daniel N., Cull, Joshua J., Markou, Thomais, Cooper, Susanna T.E., Haines, Zoe H.R., Fuller, Stephen J., O’Gara, Peter, Sheppard, Mary N., Harding, Sian E., Sugden, Peter H., Clerk, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2020
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480944/
https://ncbi.nlm.nih.gov/pubmed/32903101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14556
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