Redox Regulation of Cardiac ASK1 (Apoptosis Signal-Regulating Kinase 1) Controls p38-MAPK (Mitogen-Activated Protein Kinase) and Orchestrates Cardiac Remodeling to Hypertension

Systemic hypertension increases cardiac workload causing cardiomyocyte hypertrophy and increased cardiac fibrosis. An underlying feature is increased production of reactive oxygen species. Redox-sensitive ASK1 (apoptosis signal-regulating kinase 1) activates stress-regulated protein kinases (p38-MAP...

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Enregistré dans:
Détails bibliographiques
Publié dans:Hypertension
Auteurs principaux: Meijles, Daniel N., Cull, Joshua J., Markou, Thomais, Cooper, Susanna T.E., Haines, Zoe H.R., Fuller, Stephen J., O’Gara, Peter, Sheppard, Mary N., Harding, Sian E., Sugden, Peter H., Clerk, Angela
Format: Artigo
Langue:Inglês
Publié: Lippincott Williams & Wilkins 2020
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480944/
https://ncbi.nlm.nih.gov/pubmed/32903101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.119.14556
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