Regulation of the cardiomyocyte transcriptome vs translatome by endothelin-1 and insulin: translational regulation of 5' terminal oligopyrimidine tract (TOP) mRNAs by insulin

BACKGROUND: Changes in cellular phenotype result from underlying changes in mRNA transcription and translation. Endothelin-1 stimulates cardiomyocyte hypertrophy with associated changes in mRNA/protein expression and an increase in the rate of protein synthesis. Insulin also increases the rate of tr...

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Main Authors: Markou, Thomais, Marshall, Andrew K, Cullingford, Timothy E, Tham, El L, Sugden, Peter H, Clerk, Angela
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900265/
https://ncbi.nlm.nih.gov/pubmed/20509958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-343
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