ERK1/2 Signaling Dominates Over RhoA Signaling in Regulating Early Changes in RNA Expression Induced by Endothelin-1 in Neonatal Rat Cardiomyocytes

BACKGROUND: Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g. endothelin-1)] regulate gene expression and are implicated in the response, but their relative significance in r...

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Détails bibliographiques
Auteurs principaux: Marshall, Andrew K., Barrett, Oliver P. T., Cullingford, Timothy E., Shanmugasundram, Achchuthan, Sugden, Peter H., Clerk, Angela
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848868/
https://ncbi.nlm.nih.gov/pubmed/20368814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010027
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