Llwytho...

The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

Sequential processing of the amyloid precursor protein (APP) by β- and γ-secretases generates the Aβ peptide, a major constituent of the senile plaques observed in Alzheimer's disease. The cleavage by γ-secretase also results in the cytoplasmic release of a 59- or 57-residue-long C-terminal fra...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gao, Yuehua, Pimplikar, Sanjay W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The National Academy of Sciences 2001
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC64969/
https://ncbi.nlm.nih.gov/pubmed/11742091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261463298
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