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The γ-secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus
Sequential processing of the amyloid precursor protein (APP) by β- and γ-secretases generates the Aβ peptide, a major constituent of the senile plaques observed in Alzheimer's disease. The cleavage by γ-secretase also results in the cytoplasmic release of a 59- or 57-residue-long C-terminal fra...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The National Academy of Sciences
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC64969/ https://ncbi.nlm.nih.gov/pubmed/11742091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261463298 |
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