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Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation
The cytoplasm seems to provide an environment that favors conversion of the prion protein (PrP) to a form with the physical characteristics of the PrP(Sc) conformation, which is associated with transmissible spongiform encephalopathies. However, it is not clear whether PrP would ever exist in the cy...
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| Asıl Yazarlar: | , |
|---|---|
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
The National Academy of Sciences
2001
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC64965/ https://ncbi.nlm.nih.gov/pubmed/11742063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.011578098 |
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