Hepatotoxicity Induced by Isoniazid-Lipopolysaccharide through Endoplasmic Reticulum Stress, Autophagy, and Apoptosis Pathways in Zebrafish

Isoniazid (INH) is a first-line antituberculosis drug. The incidence of adverse reactions accompanied by inflammation in the liver during drug administration to tuberculosis patients is high and severely affects clinical treatment. To better understand the mechanism of hepatotoxicity induced by INH...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Zhang, Yun, Cen, Juan, Jia, Zhili, Hsiao, Chung-Der, Xia, Qing, Wang, Xue, Chen, Xiqiang, Wang, Rongchun, Jiang, Zhenzhou, Zhang, Luyong, Liu, Kechun
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496066/
https://ncbi.nlm.nih.gov/pubmed/30858204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01639-18
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