Liver Fatty Acid Binding Protein Deficiency Provokes Oxidative Stress, Inflammation, and Apoptosis-Mediated Hepatotoxicity Induced by Pyrazinamide in Zebrafish Larvae

Pyrazinamide (PZA) is an essential antitubercular drug, but little is still known about its hepatotoxicity potential. This study examined the effects of PZA exposure on zebrafish (Danio rerio) larvae and the mechanisms underlying its hepatotoxicity. A transgenic line of zebrafish larvae that express...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Zhang, Yun, Liu, Kechun, Hassan, Hozeifa M., Guo, Hongli, Ding, Pingping, Han, Liwen, He, Qiuxia, Chen, Weiyun, Hsiao, Chung-Der, Zhang, Luyong, Jiang, Zhenzhou
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2016
Schlagworte:
Pharmacology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119016/
https://ncbi.nlm.nih.gov/pubmed/27697757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01693-16
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