Liver Fatty Acid Binding Protein Deficiency Provokes Oxidative Stress, Inflammation, and Apoptosis-Mediated Hepatotoxicity Induced by Pyrazinamide in Zebrafish Larvae

Pyrazinamide (PZA) is an essential antitubercular drug, but little is still known about its hepatotoxicity potential. This study examined the effects of PZA exposure on zebrafish (Danio rerio) larvae and the mechanisms underlying its hepatotoxicity. A transgenic line of zebrafish larvae that express...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Zhang, Yun, Liu, Kechun, Hassan, Hozeifa M., Guo, Hongli, Ding, Pingping, Han, Liwen, He, Qiuxia, Chen, Weiyun, Hsiao, Chung-Der, Zhang, Luyong, Jiang, Zhenzhou
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5119016/
https://ncbi.nlm.nih.gov/pubmed/27697757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01693-16
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