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Mechanisms of Soft and Hard Electrophile Toxicities

Electron-deficient chemicals (electrophiles) react with compounds that have one or more unshared valence electron pairs (nucleophiles). The resulting covalent reactions between electrophiles and nucleophiles (e.g., Michael addition, S(N)2 reactions) are important, not only to Organic Chemistry, but...

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Detalhes bibliográficos
Publicado no:Toxicology
Main Authors: LoPachin, Richard M., Geohagen, Brian C., Nordstroem, Lars U
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494464/
https://ncbi.nlm.nih.gov/pubmed/30826385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2019.02.005
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