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REACTIONS OF ELECTROPHILES WITH NUCLEOPHILIC THIOLATE SITES: RELEVANCE TO PATHOPHYSIOLOGICAL MECHANISMS AND REMEDIATION

Electrophiles are electron deficient species that form covalent bonds with electron rich nucleophiles. In biological systems, reversible electrophile-nucleophile interactions mediate basal cytophysiological functions (e.g., enzyme regulation through S-nitrosylation), whereas irreversible electrophil...

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Detalhes bibliográficos
Publicado no:Free Radic Res
Main Authors: LoPachin, Richard M., Gavin, Terrence
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949956/
https://ncbi.nlm.nih.gov/pubmed/26559119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/10715762.2015.1094184
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