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Molecular Mechanisms of the Conjugated α,β-Unsaturated Carbonyl Derivatives: Relevance to Neurotoxicity and Neurodegenerative Diseases

Conjugated α,β-unsaturated carbonyl derivatives such acrylamide, acrolein, and 4-hydroxy-2-nonenal (HNE) are members of a large class of chemicals known as the type-2 alkenes. Human exposure through diet, occupation, and pollution is pervasive and has been linked to toxicity in most major organs. Ev...

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Autors principals: LoPachin, Richard M., Barber, David S., Gavin, Terrence
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734294/
https://ncbi.nlm.nih.gov/pubmed/18083715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfm301
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