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MOLECULAR MECHANISMS OF 4-HYDROXY-2-NONENAL AND ACROLEIN TOXICITY: NUCLEOPHILIC TARGETS AND ADDUCT FORMATION

Acrolein and 4-hydroxy-2-nonenal (HNE) are by-products of lipid peroxidation and are thought to play central roles in various traumatic injuries and disease states that involve cellular oxidative stress; e.g., spinal cord trauma, diabetes, Alzheimer's disease. In this Commentary, we will discus...

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Detalhes bibliográficos
Publicado no:Chem Res Toxicol
Main Authors: LoPachin, Richard M., Gavin, Terrence, Petersen, Dennis R., Barber, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4452948/
https://ncbi.nlm.nih.gov/pubmed/19610654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900147g
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