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MOLECULAR MECHANISMS OF 4-HYDROXY-2-NONENAL AND ACROLEIN TOXICITY: NUCLEOPHILIC TARGETS AND ADDUCT FORMATION
Acrolein and 4-hydroxy-2-nonenal (HNE) are by-products of lipid peroxidation and are thought to play central roles in various traumatic injuries and disease states that involve cellular oxidative stress; e.g., spinal cord trauma, diabetes, Alzheimer's disease. In this Commentary, we will discus...
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| Veröffentlicht in: | Chem Res Toxicol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4452948/ https://ncbi.nlm.nih.gov/pubmed/19610654 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx900147g |
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