PROTEIN TARGETS OF ACRYLAMIDE ADDUCT FORMATION IN CULTURED RAT DOPAMINERGIC CELLS

Acrylamide (ACR) is an electrophilic unsaturated carbonyl derivative that produces neurotoxicity by forming irreversible Michael-type adducts with nucleophilic sulfhydryl thiolate groups on cysteine residues of neuronal proteins. Identifying specific proteins targeted by ACR can lead to a better mec...

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Auteurs principaux: Martyniuk, Christopher J., Feswick, April, Fang, Bin, Koomen, John M., Barber, David S., Gavin, Terrence, LoPachin, Richard M.
Format: Artigo
Langue:Inglês
Publié: 2013
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3707521/
https://ncbi.nlm.nih.gov/pubmed/23566896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2013.03.031
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