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Mechanisms of Soft and Hard Electrophile Toxicities

Electron-deficient chemicals (electrophiles) react with compounds that have one or more unshared valence electron pairs (nucleophiles). The resulting covalent reactions between electrophiles and nucleophiles (e.g., Michael addition, S(N)2 reactions) are important, not only to Organic Chemistry, but...

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Publicat a:Toxicology
Autors principals: LoPachin, Richard M., Geohagen, Brian C., Nordstroem, Lars U
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494464/
https://ncbi.nlm.nih.gov/pubmed/30826385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2019.02.005
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