A DNA Methyltransferase Inhibitor, 5‐Aza‐2′‐Deoxycytidine, Exacerbates Neurotoxicity and Upregulates Parkinson's Disease‐Related Genes in Dopaminergic Neurons

AIMS: To investigate effects of DNA methyltransferase (DNMT) inhibitors on dopaminergic neurons and its underlied mechanism. METHODS: The DNMT inhibitor 5‐aza‐2′‐deoxycytidine (5‐aza‐dC) was tested in cultured dopaminergic cells. Cell viability and apoptosis were assayed with 5‐aza‐dC alone. Neuroto...

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Bibliografiske detaljer
Udgivet i:CNS Neurosci Ther
Main Authors: Wang, Yong, Wang, Xuan, Li, Ran, Yang, Zhao‐Fei, Wang, Yi‐Zheng, Gong, Xiao‐Li, Wang, Xiao‐Min
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2013
Fag:
Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493528/
https://ncbi.nlm.nih.gov/pubmed/23441691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12059
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