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A DNA Methyltransferase Inhibitor, 5‐Aza‐2′‐Deoxycytidine, Exacerbates Neurotoxicity and Upregulates Parkinson's Disease‐Related Genes in Dopaminergic Neurons
AIMS: To investigate effects of DNA methyltransferase (DNMT) inhibitors on dopaminergic neurons and its underlied mechanism. METHODS: The DNMT inhibitor 5‐aza‐2′‐deoxycytidine (5‐aza‐dC) was tested in cultured dopaminergic cells. Cell viability and apoptosis were assayed with 5‐aza‐dC alone. Neuroto...
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| Publicado no: | CNS Neurosci Ther |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6493528/ https://ncbi.nlm.nih.gov/pubmed/23441691 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12059 |
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