Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine in anaplastic large cell lymphoma

DNA methylation is an epigenetic mechanism establishing long-term gene silencing during development and cell commitment, which is maintained in subsequent cell generations. Aberrant DNA methylation is found at gene promoters in most cancers and can lead to silencing of tumor suppressor genes. The DN...

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Detalhes bibliográficos
Main Authors: Hassler, Melanie R., Klisaroska, Aleksandra, Kollmann, Karoline, Steiner, Irene, Bilban, Martin, Schiefer, Ana-Iris, Sexl, Veronika, Egger, Gerda
Formato: Artigo
Idioma:Inglês
Publicado em: Editions Scientifiques Elsevier 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480637/
https://ncbi.nlm.nih.gov/pubmed/22687603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2012.05.029
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