Antineoplastic activity of the DNA methyltransferase inhibitor 5-aza-2′-deoxycytidine in anaplastic large cell lymphoma

DNA methylation is an epigenetic mechanism establishing long-term gene silencing during development and cell commitment, which is maintained in subsequent cell generations. Aberrant DNA methylation is found at gene promoters in most cancers and can lead to silencing of tumor suppressor genes. The DN...

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Hlavní autoři: Hassler, Melanie R., Klisaroska, Aleksandra, Kollmann, Karoline, Steiner, Irene, Bilban, Martin, Schiefer, Ana-Iris, Sexl, Veronika, Egger, Gerda
Médium: Artigo
Jazyk:Inglês
Vydáno: Editions Scientifiques Elsevier 2012
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3480637/
https://ncbi.nlm.nih.gov/pubmed/22687603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biochi.2012.05.029
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