A New Motif in the N‐Terminal of Acetylcholinesterase Triggers Amyloid‐β Aggregation and Deposition

BACKGROUND AND PURPOSE: As a molecular chaperone, acetylcholinesterase (AChE; EC 3.1.1.7) plays a critical role in the pathogenesis of Alzheimer's disease (AD). The peripheral anionic site (PAS) of AChE has been indicated as the amyloid‐β (Aβ) binding domain. The goal of this study was to deter...

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Enregistré dans:
Détails bibliographiques
Publié dans:CNS Neurosci Ther
Auteurs principaux: Hou, Li‐Na, Xu, Jian‐Rong, Zhao, Qing‐Nan, Gao, Xiao‐Ling, Cui, Yong‐Yao, Xu, Jun, Wang, Hao, Chen, Hong‐Zhuan
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2013
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493010/
https://ncbi.nlm.nih.gov/pubmed/23981668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12161
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