A New Motif in the N‐Terminal of Acetylcholinesterase Triggers Amyloid‐β Aggregation and Deposition

BACKGROUND AND PURPOSE: As a molecular chaperone, acetylcholinesterase (AChE; EC 3.1.1.7) plays a critical role in the pathogenesis of Alzheimer's disease (AD). The peripheral anionic site (PAS) of AChE has been indicated as the amyloid‐β (Aβ) binding domain. The goal of this study was to deter...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Hou, Li‐Na, Xu, Jian‐Rong, Zhao, Qing‐Nan, Gao, Xiao‐Ling, Cui, Yong‐Yao, Xu, Jun, Wang, Hao, Chen, Hong‐Zhuan
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2013
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493010/
https://ncbi.nlm.nih.gov/pubmed/23981668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12161
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