A New Motif in the N‐Terminal of Acetylcholinesterase Triggers Amyloid‐β Aggregation and Deposition

BACKGROUND AND PURPOSE: As a molecular chaperone, acetylcholinesterase (AChE; EC 3.1.1.7) plays a critical role in the pathogenesis of Alzheimer's disease (AD). The peripheral anionic site (PAS) of AChE has been indicated as the amyloid‐β (Aβ) binding domain. The goal of this study was to deter...

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Bibliographic Details
Published in:CNS Neurosci Ther
Main Authors: Hou, Li‐Na, Xu, Jian‐Rong, Zhao, Qing‐Nan, Gao, Xiao‐Ling, Cui, Yong‐Yao, Xu, Jun, Wang, Hao, Chen, Hong‐Zhuan
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2013
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493010/
https://ncbi.nlm.nih.gov/pubmed/23981668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12161
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