A New Motif in the N‐Terminal of Acetylcholinesterase Triggers Amyloid‐β Aggregation and Deposition

BACKGROUND AND PURPOSE: As a molecular chaperone, acetylcholinesterase (AChE; EC 3.1.1.7) plays a critical role in the pathogenesis of Alzheimer's disease (AD). The peripheral anionic site (PAS) of AChE has been indicated as the amyloid‐β (Aβ) binding domain. The goal of this study was to deter...

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Publicado en:CNS Neurosci Ther
Autores principales: Hou, Li‐Na, Xu, Jian‐Rong, Zhao, Qing‐Nan, Gao, Xiao‐Ling, Cui, Yong‐Yao, Xu, Jun, Wang, Hao, Chen, Hong‐Zhuan
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2013
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Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493010/
https://ncbi.nlm.nih.gov/pubmed/23981668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12161
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