Tau local structure shields an amyloid-forming motif and controls aggregation propensity

Tauopathies are neurodegenerative diseases characterized by intracellular amyloid deposits of tau protein. Missense mutations in the tau gene (MAPT) correlate with aggregation propensity and cause dominantly inherited tauopathies, but their biophysical mechanism driving amyloid formation is poorly u...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Chen, Dailu, Drombosky, Kenneth W., Hou, Zhiqiang, Sari, Levent, Kashmer, Omar M., Ryder, Bryan D., Perez, Valerie A., Woodard, DaNae R., Lin, Milo M., Diamond, Marc I., Joachimiak, Lukasz A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6555816/
https://ncbi.nlm.nih.gov/pubmed/31175300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10355-1
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