A New Motif in the N‐Terminal of Acetylcholinesterase Triggers Amyloid‐β Aggregation and Deposition

BACKGROUND AND PURPOSE: As a molecular chaperone, acetylcholinesterase (AChE; EC 3.1.1.7) plays a critical role in the pathogenesis of Alzheimer's disease (AD). The peripheral anionic site (PAS) of AChE has been indicated as the amyloid‐β (Aβ) binding domain. The goal of this study was to deter...

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Bibliographische Detailangaben
Veröffentlicht in:CNS Neurosci Ther
Hauptverfasser: Hou, Li‐Na, Xu, Jian‐Rong, Zhao, Qing‐Nan, Gao, Xiao‐Ling, Cui, Yong‐Yao, Xu, Jun, Wang, Hao, Chen, Hong‐Zhuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2013
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6493010/
https://ncbi.nlm.nih.gov/pubmed/23981668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12161
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