Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in‐coordination in rats with hepatic encephalopathy

AIMS: Patients with liver disease may develop hepatic encephalopathy (HE), with cognitive impairment and motor in‐coordination. Rats with HE due to portacaval shunts (PCS) show motor in‐coordination. We hypothesized that in PCS rats: (i) Motor in‐coordination would be due to enhanced GABAergic tone...

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Détails bibliographiques
Publié dans:CNS Neurosci Ther
Auteurs principaux: Agusti, Ana, Hernández‐Rabaza, Vicente, Balzano, Tiziano, Taoro‐Gonzalez, Lucas, Ibañez‐Grau, Andrea, Cabrera‐Pastor, Andrea, Fustero, Santos, Llansola, Marta, Montoliu, Carmina, Felipo, Vicente
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2017
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492705/
https://ncbi.nlm.nih.gov/pubmed/28296282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12688
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