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Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in‐coordination in rats with hepatic encephalopathy

AIMS: Patients with liver disease may develop hepatic encephalopathy (HE), with cognitive impairment and motor in‐coordination. Rats with HE due to portacaval shunts (PCS) show motor in‐coordination. We hypothesized that in PCS rats: (i) Motor in‐coordination would be due to enhanced GABAergic tone...

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Bibliografiske detaljer
Udgivet i:CNS Neurosci Ther
Main Authors: Agusti, Ana, Hernández‐Rabaza, Vicente, Balzano, Tiziano, Taoro‐Gonzalez, Lucas, Ibañez‐Grau, Andrea, Cabrera‐Pastor, Andrea, Fustero, Santos, Llansola, Marta, Montoliu, Carmina, Felipo, Vicente
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492705/
https://ncbi.nlm.nih.gov/pubmed/28296282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12688
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