Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in‐coordination in rats with hepatic encephalopathy

AIMS: Patients with liver disease may develop hepatic encephalopathy (HE), with cognitive impairment and motor in‐coordination. Rats with HE due to portacaval shunts (PCS) show motor in‐coordination. We hypothesized that in PCS rats: (i) Motor in‐coordination would be due to enhanced GABAergic tone...

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Vydáno v:CNS Neurosci Ther
Hlavní autoři: Agusti, Ana, Hernández‐Rabaza, Vicente, Balzano, Tiziano, Taoro‐Gonzalez, Lucas, Ibañez‐Grau, Andrea, Cabrera‐Pastor, Andrea, Fustero, Santos, Llansola, Marta, Montoliu, Carmina, Felipo, Vicente
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492705/
https://ncbi.nlm.nih.gov/pubmed/28296282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12688
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