Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

BACKGROUND: Patients with liver cirrhosis and minimal hepatic encephalopathy (MHE) show mild cognitive impairment and spatial learning dysfunction. Hyperammonemia acts synergistically with inflammation to induce cognitive impairment in MHE. Hyperammonemia-induced neuroinflammation in hippocampus cou...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Hernández-Rabaza, Vicente, Cabrera-Pastor, Andrea, Taoro-González, Lucas, Malaguarnera, Michele, Agustí, Ana, Llansola, Marta, Felipo, Vicente
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754839/
https://ncbi.nlm.nih.gov/pubmed/26883214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0505-y
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados