Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

BACKGROUND: Patients with liver cirrhosis and minimal hepatic encephalopathy (MHE) show mild cognitive impairment and spatial learning dysfunction. Hyperammonemia acts synergistically with inflammation to induce cognitive impairment in MHE. Hyperammonemia-induced neuroinflammation in hippocampus cou...

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Bibliographic Details
Published in:J Neuroinflammation
Main Authors: Hernández-Rabaza, Vicente, Cabrera-Pastor, Andrea, Taoro-González, Lucas, Malaguarnera, Michele, Agustí, Ana, Llansola, Marta, Felipo, Vicente
Format: Artigo
Language:Inglês
Published: BioMed Central 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4754839/
https://ncbi.nlm.nih.gov/pubmed/26883214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-016-0505-y
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