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Sildenafil reduces neuroinflammation in cerebellum, restores GABAergic tone, and improves motor in‐coordination in rats with hepatic encephalopathy

AIMS: Patients with liver disease may develop hepatic encephalopathy (HE), with cognitive impairment and motor in‐coordination. Rats with HE due to portacaval shunts (PCS) show motor in‐coordination. We hypothesized that in PCS rats: (i) Motor in‐coordination would be due to enhanced GABAergic tone...

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Detalhes bibliográficos
Publicado no:CNS Neurosci Ther
Main Authors: Agusti, Ana, Hernández‐Rabaza, Vicente, Balzano, Tiziano, Taoro‐Gonzalez, Lucas, Ibañez‐Grau, Andrea, Cabrera‐Pastor, Andrea, Fustero, Santos, Llansola, Marta, Montoliu, Carmina, Felipo, Vicente
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492705/
https://ncbi.nlm.nih.gov/pubmed/28296282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cns.12688
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