Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

BACKGROUND: MSA is a fatal neurodegenerative disease characterized by autonomic failure and severe motor impairment. Its main pathological hallmark is the accumulation of α‐synuclein in oligodendrocytes, leading to glial and neuronal dysfunction and neurodegeneration. These features are recapitulate...

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Publicado en:Mov Disord
Autores principales: Heras‐Garvin, Antonio, Weckbecker, Daniel, Ryazanov, Sergey, Leonov, Andrei, Griesinger, Christian, Giese, Armin, Wenning, Gregor K., Stefanova, Nadia
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley & Sons, Inc. 2018
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492169/
https://ncbi.nlm.nih.gov/pubmed/30452793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.27562
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