Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

BACKGROUND: MSA is a fatal neurodegenerative disease characterized by autonomic failure and severe motor impairment. Its main pathological hallmark is the accumulation of α‐synuclein in oligodendrocytes, leading to glial and neuronal dysfunction and neurodegeneration. These features are recapitulate...

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Bibliografiske detaljer
Udgivet i:Mov Disord
Main Authors: Heras‐Garvin, Antonio, Weckbecker, Daniel, Ryazanov, Sergey, Leonov, Andrei, Griesinger, Christian, Giese, Armin, Wenning, Gregor K., Stefanova, Nadia
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Inc. 2018
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Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492169/
https://ncbi.nlm.nih.gov/pubmed/30452793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.27562
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