Targeting α-synuclein by PD03 AFFITOPE® and Anle138b rescues neurodegenerative pathology in a model of multiple system atrophy: clinical relevance

BACKGROUND: Misfolded oligomeric α-synuclein plays a pivotal role in the pathogenesis of α-synucleinopathies including Parkinson’s disease and multiple system atrophy, and its detection parallels activation of microglia and a loss of neurons in the substantia nigra pars compacta. Here we aimed to an...

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Detalhes bibliográficos
Publicado no:Transl Neurodegener
Main Authors: Lemos, Miguel, Venezia, Serena, Refolo, Violetta, Heras-Garvin, Antonio, Schmidhuber, Sabine, Giese, Armin, Leonov, Andrei, Ryazanov, Sergey, Griesinger, Christian, Galabova, Gergana, Staffler, Guenther, Wenning, Gregor Karl, Stefanova, Nadia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7513530/
https://ncbi.nlm.nih.gov/pubmed/32972456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40035-020-00217-y
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