Anle138b modulates α‐synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy

BACKGROUND: MSA is a fatal neurodegenerative disease characterized by autonomic failure and severe motor impairment. Its main pathological hallmark is the accumulation of α‐synuclein in oligodendrocytes, leading to glial and neuronal dysfunction and neurodegeneration. These features are recapitulate...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mov Disord
Egile Nagusiak: Heras‐Garvin, Antonio, Weckbecker, Daniel, Ryazanov, Sergey, Leonov, Andrei, Griesinger, Christian, Giese, Armin, Wenning, Gregor K., Stefanova, Nadia
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley & Sons, Inc. 2018
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492169/
https://ncbi.nlm.nih.gov/pubmed/30452793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mds.27562
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