An Activity‐Based Probe Targeting Non‐Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

Bromodomain‐containing proteins are epigenetic modulators involved in a wide range of cellular processes, from recruitment of transcription factors to pathological disruption of gene regulation and cancer development. Since the druggability of these acetyl‐lysine reader domains was established, effo...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: D'Ascenzio, Melissa, Pugh, Kathryn M., Konietzny, Rebecca, Berridge, Georgina, Tallant, Cynthia, Hashem, Shaima, Monteiro, Octovia, Thomas, Jason R., Schirle, Markus, Knapp, Stefan, Marsden, Brian, Fedorov, Oleg, Bountra, Chas, Kessler, Benedikt M., Brennan, Paul E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492141/
https://ncbi.nlm.nih.gov/pubmed/30589164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201807825
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