An Activity‐Based Probe Targeting Non‐Catalytic, Highly Conserved Amino Acid Residues within Bromodomains

Bromodomain‐containing proteins are epigenetic modulators involved in a wide range of cellular processes, from recruitment of transcription factors to pathological disruption of gene regulation and cancer development. Since the druggability of these acetyl‐lysine reader domains was established, effo...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: D'Ascenzio, Melissa, Pugh, Kathryn M., Konietzny, Rebecca, Berridge, Georgina, Tallant, Cynthia, Hashem, Shaima, Monteiro, Octovia, Thomas, Jason R., Schirle, Markus, Knapp, Stefan, Marsden, Brian, Fedorov, Oleg, Bountra, Chas, Kessler, Benedikt M., Brennan, Paul E.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6492141/
https://ncbi.nlm.nih.gov/pubmed/30589164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201807825
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