Synthesis and Biological Evaluation of 4β-N-Acetylamino Substituted Podophyllotoxin Derivatives as Novel Anticancer Agents

A series of novel podophyllotoxin derivatives obtained by 4β-N-acetylamino substitution at C-4 position was designed, synthesized, and evaluated for in vitro cytotoxicity against four human cancer cell lines (EC-9706, HeLA, T-24 and H460) and a normal human epidermal cell line (HaCaT). The cytotoxic...

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Udgivet i:Front Chem
Main Authors: Wei, Jinbao, Chen, Jinghong, Ju, Peijun, Ma, Le, Chen, Li, Ma, Weidong, Zheng, Tao, Yang, Guangyi, Wang, Yong-Xiang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Chemistry
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491884/
https://ncbi.nlm.nih.gov/pubmed/31106192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00253
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