Supraspinal and Peripheral, but Not Intrathecal, σ(1)R Blockade by S1RA Enhances Morphine Antinociception

Sigma-1 receptor (σ(1)R) antagonism increases the effects of morphine on acute nociceptive pain. S1RA (E-52862) is a selective σ(1)R antagonist widely used to study the role of σ(1)Rs. S1RA alone exerted antinociceptive effect in the formalin test in rats and increased noradrenaline levels in the sp...

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Detaylı Bibliyografya
Yayımlandı:Front Pharmacol
Asıl Yazarlar: Vidal-Torres, Alba, Fernández-Pastor, Begoña, Carceller, Alicia, Vela, José Miguel, Merlos, Manuel, Zamanillo, Daniel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Frontiers Media S.A. 2019
Konular:
Pharmacology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491787/
https://ncbi.nlm.nih.gov/pubmed/31068818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00422
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