Supraspinal and Peripheral, but Not Intrathecal, σ(1)R Blockade by S1RA Enhances Morphine Antinociception

Sigma-1 receptor (σ(1)R) antagonism increases the effects of morphine on acute nociceptive pain. S1RA (E-52862) is a selective σ(1)R antagonist widely used to study the role of σ(1)Rs. S1RA alone exerted antinociceptive effect in the formalin test in rats and increased noradrenaline levels in the sp...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Pharmacol
Prif Awduron: Vidal-Torres, Alba, Fernández-Pastor, Begoña, Carceller, Alicia, Vela, José Miguel, Merlos, Manuel, Zamanillo, Daniel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Pharmacology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6491787/
https://ncbi.nlm.nih.gov/pubmed/31068818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00422
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