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Supraspinal and Peripheral, but Not Intrathecal, σ(1)R Blockade by S1RA Enhances Morphine Antinociception
Sigma-1 receptor (σ(1)R) antagonism increases the effects of morphine on acute nociceptive pain. S1RA (E-52862) is a selective σ(1)R antagonist widely used to study the role of σ(1)Rs. S1RA alone exerted antinociceptive effect in the formalin test in rats and increased noradrenaline levels in the sp...
Shranjeno v:
| izdano v: | Front Pharmacol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6491787/ https://ncbi.nlm.nih.gov/pubmed/31068818 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00422 |
| Oznake: |
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