In vitro study of the Polo‐like kinase 1 inhibitor volasertib in non‐small‐cell lung cancer reveals a role for the tumor suppressor p53

Polo‐like kinase 1 (Plk1), a master regulator of mitosis and the DNA damage response, is considered to be an intriguing target in the research field of mitotic intervention. The observation that Plk1 is overexpressed in multiple human malignancies, including non‐small‐cell lung cancer (NSCLC), gave...

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Dettagli Bibliografici
Pubblicato in:Mol Oncol
Autori principali: Van den Bossche, Jolien, Deben, Christophe, De Pauw, Ines, Lambrechts, Hilde, Hermans, Christophe, Deschoolmeester, Vanessa, Jacobs, Julie, Specenier, Pol, Pauwels, Patrick, Vermorken, Jan Baptist, Peeters, Marc, Lardon, Filip, Wouters, An
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6487694/
https://ncbi.nlm.nih.gov/pubmed/30859681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12477
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