Radiosensitization of Non-Small Cell Lung Cancer Cells by the Plk1 Inhibitor Volasertib Is Dependent on the p53 Status

Polo-like kinase 1 (Plk1), a master regulator of mitotic cell division, is highly expressed in non-small cell lung cancer (NSCLC) making it an interesting drug target. We examined the in vitro therapeutic effects of volasertib, a Plk1 inhibitor, in combination with irradiation in a panel of NSCLC ce...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Principais autores: Van den Bossche, Jolien, Domen, Andreas, Peeters, Marc, Deben, Christophe, De Pauw, Ines, Jacobs, Julie, De Bruycker, Sven, Specenier, Pol, Pauwels, Patrick, Vermorken, Jan Baptist, Lardon, Filip, Wouters, An
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966428/
https://ncbi.nlm.nih.gov/pubmed/31795121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121893
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