Radiosensitization of Non-Small Cell Lung Cancer Cells by the Plk1 Inhibitor Volasertib Is Dependent on the p53 Status

Polo-like kinase 1 (Plk1), a master regulator of mitotic cell division, is highly expressed in non-small cell lung cancer (NSCLC) making it an interesting drug target. We examined the in vitro therapeutic effects of volasertib, a Plk1 inhibitor, in combination with irradiation in a panel of NSCLC ce...

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Detaylı Bibliyografya
Yayımlandı:Cancers (Basel)
Asıl Yazarlar: Van den Bossche, Jolien, Domen, Andreas, Peeters, Marc, Deben, Christophe, De Pauw, Ines, Jacobs, Julie, De Bruycker, Sven, Specenier, Pol, Pauwels, Patrick, Vermorken, Jan Baptist, Lardon, Filip, Wouters, An
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966428/
https://ncbi.nlm.nih.gov/pubmed/31795121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121893
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