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Overcoming Intrinsic and Acquired Cetuximab Resistance in RAS Wild-Type Colorectal Cancer: An In Vitro Study on the Expression of HER Receptors and the Potential of Afatinib

The epidermal growth factor receptor (EGFR) is an important therapeutic target in colorectal cancer (CRC). After the initial promising results of EGFR-targeted therapies such as cetuximab, therapeutic resistance poses a challenging problem and limits the success of effective anti-EGFR cancer therapi...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: De Pauw, Ines, Lardon, Filip, Van den Bossche, Jolien, Baysal, Hasan, Pauwels, Patrick, Peeters, Marc, Vermorken, Jan Baptist, Wouters, An
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6357064/
https://ncbi.nlm.nih.gov/pubmed/30650638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11010098
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